Shanthakumar Shantha Tyavanagimatt

Chief Technical Officer, SVP at Geron Corporation

South San Francisco, California, United States

About Shanthakumar Shantha Tyavanagimatt

Shanthakumar Shantha Tyavanagimatt is Chief Technical Officer, SVP at Geron Corporation. Location: South San Francisco, California, United States.

I love making a difference in people’s lives through innovative medicines. As a dynamic and forward-thinking pharmaceutical executive, I bring a patient-centric emphasis and an enterprise-wide perspective to drive development, approvals, and launch of life-changing products. With extensive expertise in transitioning development-stage organizations into commercial success, I have played a pivotal role in achieving corporate growth. Proven leadership in early and late-stage CMC development, technical & QA operations, process development, manufacturing, supply chain, drug development, clinical pharmacology, Phase-1 clinical design & Operations, regulatory affairs, and commercialization. Achieved 4 NDA/MAA approvals, spearheaded several 505(b)2 products & ANDAs, and managed over 30 IND/IMPDs (phase 1-3 CT). Some of my key skills and accomplishments include: • Providing strategic leadership, implementing CMC and drug development solutions to ensure “right the first time” approvals and global expansion • Building and managing global CMC Tech Ops, clinical Pharmacology, preclinical, program management, and high performance teams • Played pivotal role in CTI’s growth from $100M in 2016 to $1.7Bn acquisition in 2023 • Generated over $500M in revenue from successful product launches for SIGA Technologies • Reduced costs by 25% through efficient supply chain management and contract negotiations • Leading technical due diligence for new drugs in-licensing, M&A activities, and portfolio development • Developing and managing budgets, P&L, corporate value creation, risk management, life cycle management, change management, competitive intelligence, organizational development, and transformation My leadership style emphasizes initiative, innovation, communication, collaboration, influence, honesty, and a focus on operational excellence, consistently delivering results. My mission is to ensure the safety, efficacy, and compliance of the new medicines we develop so patients can look forward to stronger and longer lives. Feel free to reach out if you’re interested in collaborating on cutting-edge pharmaceutical projects. I’d love to hear from you.

Skills

  • Product Development
  • Regulatory Strategy
  • Regulatory Compliance

Additional experience

  • Senior Vice President, Technical Operations

    IDEAYA Biosciences

    April 2025 – October 2025

Education

  • post-doc, University of Utah
  • PH.D, The Maharaja Sayajirao University of Baroda (MSUB), Vadodara